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Similarly, both in vivo feeding with a choline-rich diet and in vitro trimethylamine-N-oxidase (TMAO) stimulation increased TMAO-dependent NLRP3 inflammasome activation and expression of IL-1β, IL6, TNF-α, CXCL9, and CXCL10, supporting that NLRP3 is a key proteolytic activator in the macrophage response to a high choline and TMAO production (80) ( Figure 3 )

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One of the researchers in the study pointed out that the mild and rare side effects that occurred with CoQ10 were mild compared to side effects that occur with anti-migraine medications such as beta blockers